Across TCGA pan-cancer cohorts, NDUFB4P8 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NDUFB4P8’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where NDUFB4P8 RNA is repressed in tumor relative to normal tissue. In most cancer types NDUFB4P8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA, LIHC, and STAD are the cancer types where NDUFB4P8 tumor–normal differential expression is most reproducible.