NDUFB4

Across TCGA pan-cancer cohorts, NDUFB4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFB4 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFB4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFB4 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

PDAC, GBM, and HNSC are the cancer types where NDUFB4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.179	0.720	<.001	15	view →
GBM	OS	Tertile	All	0.932	0.671	.019	8	view →
HNSC	DFS	Tertile	III,IV	0.796	0.501	.018	6	view →
OV	DFS	Median	All	1.000	0.866	.040	4	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	4	view →
LUAD	DFS	Median	All	0.893	1.000	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFB4–PDAC (OS)

Open the PDAC breakdown →