NDUFB4

Across TCGA pan-cancer cohorts, NDUFB4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NDUFB4’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NDUFB4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDUFB4 is over-expressed in tumor, although a few such as READ and KICH show the opposite, repressed pattern.

LIHC, LUAD, and HNSC are the cancer types where NDUFB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.803	<.001	9	view →
LUAD	Male	All	+0.508	<.001	9	view →
HNSC	Male	IV	+0.918	<.001	8	view →
KIRC	Female	All	+0.529	<.001	7	view →
LUSC	Female	All	+1.085	<.001	6	view →
BRCA	All	III,IV	+0.754	<.001	6	view →
UCEC	All	II,III,IV	+0.604	<.001	6	view →
BLCA	All	All	+0.451	.015	4	view →
CHOL	All	All	+1.304	<.001	3	view →
READ	All	All	−0.352	.017	2	view →
ESCA	All	All	+0.586	.020	1	view →
KICH	All	All	−0.417	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NDUFB4–LIHC

Open the LIHC breakdown →