NDUFB4

Across TCGA patient cohorts, NDUFB4 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFB4-associated genes across cancer lineages are DUX4L4, TTTY6, and KRTAP9-8. Each is linked with NDUFB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFB4-to-partner and partner-to-NDUFB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUX4L4 grouped by NDUFB4-low versus NDUFB4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFB4→partner) and Y-score (partner→NDUFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DUX4L4 →	+0.019	+7.930	<.001	.008	3	2
LUAD	TTTY6 →	+0.044	+7.930	<.001	.008	3	1
LUAD	KRTAP9-8 →	+0.044	+7.930	<.001	.008	3	1
LUAD	RN7SKP222 →	+0.069	+7.930	<.001	.008	3	1
LUAD	FAM197Y5 →	+0.039	+7.930	<.001	.008	3	1
LUAD	LINC00709 →	+0.079	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

DUX4L4 by NDUFB4 expression — LUAD

Explore this box plot interactively →