NDUFAF4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NDUFAF4 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFAF4-associated genes across cancer lineages are Notch1 and Src. Each is linked with NDUFAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFAF4-to-partner and partner-to-NDUFAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NDUFAF4-low versus NDUFAF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFAF4→partner) and Y-score (partner→NDUFAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.242+3.000.002.03731
UCECSrc →+0.296+3.000.012.03621
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Notch1 by NDUFAF4 expression — UCEC

Box plot of Notch1 in NDUFAF4-low vs NDUFAF4-high samples in UCEC.

Explore this box plot interactively →

Exploration