NDUFAF1

Across TCGA patient cohorts, NDUFAF1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDUFAF1-associated genes across cancer lineages are Rad50, TSC1, and Bcl-xL. Each is linked with NDUFAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFAF1-to-partner and partner-to-NDUFAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by NDUFAF1-low versus NDUFAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFAF1→partner) and Y-score (partner→NDUFAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.327	-2.986	.014	.035	3	1
UCEC	TSC1 →	+0.216	+3.169	.021	.020	3	1
UCEC	Bcl-xL →	-0.240	-3.169	.006	.020	3	1
UCEC	PEA-15_pS116 →	-0.390	-3.169	.043	.020	2	1
UCEC	Axl →	+0.246	+2.818	.039	.035	2	1
UCEC	Collagen-VI →	+0.244	+3.169	.031	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rad50 by NDUFAF1 expression — UCEC

Explore this box plot interactively →