NDUFAF1

Across TCGA pan-cancer cohorts, NDUFAF1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NDUFAF1 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NDUFAF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDUFAF1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and MESO show a favorable association.

UVM, KIRP, and MESO are the cancer types where NDUFAF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.212	0.704	<.001	133	view →
KIRP	DFS	Quartile	All	0.873	0.561	.003	63	view →
MESO	DFS	Tertile	II,III,IV	0.506	0.278	.010	40	view →
LIHC	OS	Tertile	All	0.893	0.648	.002	37	view →
HNSC	DFS	Quartile	II,III,IV	0.205	0.379	.007	35	view →
KIRC	OS	Quartile	All	0.758	0.524	<.001	34	view →
UCEC	OS	Tertile	III,IV	0.807	0.479	.004	32	view →
KICH	DFS	Median	All	0.799	0.972	.014	23	view →
SARC	OS	Tertile	All	0.851	0.765	.008	20	view →
ESCA	OS	Median	III,IV	0.422	0.657	.010	19	view →
COAD	OS	Median	IV	0.493	0.803	.011	19	view →
OV	OS	Quartile	All	0.803	0.896	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NDUFAF1–UVM (DFS)

Open the UVM breakdown →