NDUFA5

Across TCGA pan-cancer cohorts, NDUFA5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDUFA5 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NDUFA5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDUFA5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where NDUFA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.640	0.306	.001	17	view →
CCRCC	OS	Median	All	1.000	0.626	.001	17	view →
COAD	DFS	Tertile	All	1.000	0.923	.047	12	view →
LUAD	OS	Quartile	II,III,IV	0.938	0.438	.007	4	view →
GBM	OS	Median	All	0.604	0.452	.035	2	view →
HNSC	DFS	Tertile	IV	0.825	0.591	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDUFA5–PDAC (DFS)

Open the PDAC breakdown →