NDUFA5

Across TCGA pan-cancer cohorts, NDUFA5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NDUFA5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NDUFA5 RNA is repressed in tumor relative to normal tissue. In most cancer types NDUFA5 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and COAD are the cancer types where NDUFA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.303	<.001	10	view →
UCEC	All	All	−0.579	<.001	8	view →
COAD	All	All	−0.574	<.001	8	view →
KIRC	Male	II,III,IV	−0.409	<.001	7	view →
BLCA	Male	III,IV	−0.611	.005	6	view →
BRCA	All	II,III,IV	+0.248	<.001	6	view →
LIHC	All	All	+0.306	<.001	4	view →
READ	All	All	−0.796	.008	2	view →
LUSC	All	III,IV	−0.520	.031	2	view →
CHOL	All	All	+0.507	<.001	2	view →
HNSC	Male	All	−0.368	.010	2	view →
LUAD	Female	II,III,IV	−0.301	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NDUFA5–THCA

Open the THCA breakdown →