NDUFA2

Across TCGA pan-cancer cohorts, NDUFA2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NDUFA2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NDUFA2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NDUFA2 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where NDUFA2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDUFA2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−1.589	<.001	12	view →
COAD	Male	II,III,IV	−0.652	<.001	12	view →
HNSC	Male	II,III,IV	−0.847	<.001	8	view →
LSCC	Female	All	+0.244	<.001	8	view →
LUAD	All	All	+0.126	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NDUFA2–CCRCC

Open the CCRCC breakdown →