NDUFA2

Across TCGA pan-cancer cohorts, NDUFA2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NDUFA2 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NDUFA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NDUFA2 expression acts as an unfavorable survival marker, although some lineages such as MESO and BLCA show a favorable association.

UVM, MESO, and UCS are the cancer types where NDUFA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.394	0.839	<.001	116	view →
MESO	DFS	Median	II,III,IV	0.525	0.283	<.001	93	view →
UCS	DFS	Median	IV	0.367	0.952	.001	72	view →
BLCA	DFS	Tertile	IV	0.554	0.191	.005	35	view →
KICH	DFS	Tertile	All	0.773	1.000	.016	33	view →
LGG	DFS	Tertile	All	0.765	0.904	.001	25	view →
ESCA	OS	Quartile	All	0.587	0.793	.016	21	view →
HNSC	OS	Quartile	IV	0.410	0.785	.007	16	view →
LUAD	OS	Tertile	II,III,IV	0.306	0.574	.005	16	view →
CESC	OS	Tertile	All	0.733	0.461	.006	14	view →
DLBC	DFS	Tertile	All	1.000	0.531	.030	10	view →
UCEC	OS	Median	IV	0.259	0.614	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NDUFA2–UVM (OS)

Open the UVM breakdown →