NDST4

Across TCGA pan-cancer cohorts, NDST4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NDST4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NDST4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NDST4 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

KIRC, PRAD, and LIHC are the cancer types where NDST4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.221	0.789	.016	30	view →
PRAD	OS	Median	All	0.770	0.990	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
LUSC	DFS	Median	III,IV	0.152	0.781	.004	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →
COAD	DFS	Median	II,III,IV	1.000	0.746	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NDST4–KIRC (OS)

Open the KIRC breakdown →