NDRG4

Across TCGA pan-cancer cohorts, NDRG4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NDRG4 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NDRG4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NDRG4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where NDRG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.987	0.875	.006	27	view →
PDAC	DFS	Tertile	II,III,IV	0.563	0.184	.039	9	view →
GBM	DFS	Tertile	All	0.268	0.481	.034	3	view →
LUAD	DFS	Median	All	0.877	0.919	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NDRG4–HNSC (DFS)

Open the HNSC breakdown →