NDRG4

Across TCGA pan-cancer cohorts, NDRG4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NDRG4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NDRG4 RNA is repressed in tumor relative to normal tissue. In most cancer types NDRG4 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and HNSC are the cancer types where NDRG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDRG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.153	<.001	9	view →
BRCA	Female	All	−0.472	<.001	8	view →
HNSC	All	All	+0.893	.003	7	view →
STAD	All	All	−0.950	.003	6	view →
COAD	Female	II,III,IV	−0.722	<.001	6	view →
THCA	Male	All	−0.563	<.001	6	view →
KIRC	Male	All	−0.297	.001	4	view →
CHOL	All	All	+1.053	<.001	3	view →
BLCA	Male	III,IV	+1.679	.019	2	view →
PRAD	All	All	−1.384	<.001	2	view →
READ	Female	All	−1.325	.002	2	view →
KIRP	All	II,III,IV	+1.022	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NDRG4–LUAD

Open the LUAD breakdown →