NDRG4

Across TCGA patient cohorts, NDRG4 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDRG4-associated genes across cancer lineages are JNK_pT183_Y185, MIG-6, and Smad3. Each is linked with NDRG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG4-to-partner and partner-to-NDRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NDRG4-low versus NDRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG4→partner) and Y-score (partner→NDRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.218	-2.649	<.001	<.001	3	2
UCEC	MIG-6 →	+0.090	+1.428	.015	.029	3	2
UCEC	Smad3 →	+0.176	+2.459	.001	.018	3	2
UCEC	Chk2_pT68 →	-0.199	-3.077	.004	<.001	3	2
UCEC	Cyclin-D1 →	+0.129	+2.321	.033	.005	3	2
UCEC	eEF2 →	+0.401	+2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

JNK_pT183_Y185 by NDRG4 expression — UCEC

Explore this box plot interactively →