NDRG2

Across TCGA cell cohorts, NDRG2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NDRG2-associated genes across cancer lineages are GRM6, DYDC1, and SPEM1. Each is linked with NDRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG2-to-partner and partner-to-NDRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by NDRG2-low versus NDRG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG2→partner) and Y-score (partner→NDRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM6 →	+0.087	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DYDC1 →	+0.024	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SPEM1 →	+0.117	+4.347	<.001	.001	3	1
LARGE_INTESTINE	FAM205C →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FAM90A26 →	+0.007	+5.099	<.001	<.001	3	1
LARGE_INTESTINE	NME8 →	+0.352	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GRM6 by NDRG2 expression — LARGE_INTESTINE

Explore this box plot interactively →