NDRG1

Across TCGA pan-cancer cohorts, NDRG1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NDRG1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NDRG1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NDRG1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where NDRG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.620	0.883	<.001	42	view →
PDAC	OS	Median	All	0.279	0.464	.003	24	view →
GBM	OS	Quartile	All	0.329	0.684	.006	12	view →
LSCC	DFS	Tertile	II,III,IV	0.945	0.787	.035	3	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.909	.022	2	view →
LUAD	OS	Quartile	All	0.936	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NDRG1–CCRCC (DFS)

Open the CCRCC breakdown →