NDRG1

Across TCGA cell cohorts, NDRG1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NDRG1-associated genes across cancer lineages are C20orf85, IL22, and SCGB3A2. Each is linked with NDRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG1-to-partner and partner-to-NDRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by NDRG1-low versus NDRG1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG1→partner) and Y-score (partner→NDRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.100	+4.922	.003	.009	3	1
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP4-9 →	+0.048	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR2A5 →	+0.021	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C20orf85 by NDRG1 expression — BLOOD_Leukemia

Explore this box plot interactively →