NDN

Across TCGA patient cohorts, NDN mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDN-associated genes across cancer lineages are GAPDH, eEF2K, and eEF2. Each is linked with NDN in more than 2 cancer types. Because this analysis shows association rather than direction, both NDN-to-partner and partner-to-NDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NDN-low versus NDN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDN→partner) and Y-score (partner→NDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.560	+3.459	.011	.005	3	3
LUSC	eEF2K →	+0.346	+2.594	.016	.006	3	2
UCEC	eEF2 →	+0.519	+2.321	<.001	.006	3	2
UCEC	Ku80 →	+0.218	+1.820	.025	.016	3	2
UCEC	p62 Lck ligand →	+0.345	+2.469	.010	.010	3	2
UCEC	PCNA →	+0.348	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GAPDH by NDN expression — UCEC

Explore this box plot interactively →