NDN

Across TCGA pan-cancer cohorts, NDN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NDN data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NDN RNA is associated with better overall survival. In most high-consensus cancer types, elevated NDN expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

UVM, UCEC, and LGG are the cancer types where NDN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.803	0.403	<.001	132	view →
UCEC	DFS	Tertile	II,III,IV	0.896	0.777	.003	58	view →
LGG	OS	Median	All	0.865	0.751	<.001	40	view →
SKCM	OS	Tertile	III,IV	0.565	0.833	<.001	30	view →
OV	OS	Quartile	IV	0.942	0.575	.006	16	view →
THCA	DFS	Median	All	0.907	0.767	.001	11	view →
SCLC	DFS	Quartile	All	0.400	0.107	.024	10	view →
STAD	OS	Tertile	All	0.535	0.669	.009	10	view →
KIRP	DFS	Quartile	All	0.817	0.933	.010	9	view →
ACC	OS	Median	IV	0.344	0.724	.038	8	view →
MESO	OS	Tertile	All	0.466	0.265	.017	7	view →
LUAD	OS	Tertile	II,III,IV	0.596	0.459	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NDN–UVM (OS)

Open the UVM breakdown →