NDN

Across TCGA cell cohorts, NDN mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NDN-associated genes across cancer lineages are ADIPOQ, NANOGNB, and SRRD. Each is linked with NDN in more than 1 cancer types. Because this analysis shows association rather than direction, both NDN-to-partner and partner-to-NDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by NDN-low versus NDN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDN→partner) and Y-score (partner→NDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADIPOQ →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NANOGNB →	+0.121	+4.887	<.001	.009	3	1
LARGE_INTESTINE	SRRD →	+0.994	+3.212	<.001	.006	3	1
LARGE_INTESTINE	SEPTIN3 →	+1.294	+3.299	.001	.004	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.657	+3.212	.001	.006	3	1
LARGE_INTESTINE	CNIH1 →	+0.646	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

ADIPOQ by NDN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →