NCSTN

Across TCGA patient cohorts, NCSTN mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCSTN-associated genes across cancer lineages are RNA5SP336, RTN4IP1, and RNU6-1067P. Each is linked with NCSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCSTN-to-partner and partner-to-NCSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP336 grouped by NCSTN-low versus NCSTN-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCSTN→partner) and Y-score (partner→NCSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP336 →	+0.160	+4.148	<.001	.008	3	2
UCEC	RTN4IP1 →	+0.336	+2.119	.007	.003	3	2
SKCM	RNU6-1067P →	+0.567	+4.237	<.001	<.001	3	2
CESC	MIR1227 →	+0.215	+4.144	<.001	.009	3	2
UCEC	TMEM126A →	+0.367	+3.376	.002	.004	3	2
COAD	TRDJ4 →	+0.635	+4.537	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

RNA5SP336 by NCSTN expression — LUSC

Explore this box plot interactively →