NCSTN

Across TCGA pan-cancer cohorts, NCSTN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NCSTN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NCSTN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCSTN is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where NCSTN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCSTN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.394	<.001	11	view →
BLCA	All	III,IV	+1.054	<.001	11	view →
LIHC	Female	II,III,IV	+1.439	<.001	9	view →
STAD	Male	II,III,IV	+0.800	<.001	9	view →
KIRC	All	All	+0.307	<.001	9	view →
KICH	Female	II,III,IV	−1.424	<.001	8	view →
LUAD	All	II,III,IV	+0.406	<.001	7	view →
UCEC	All	All	+0.855	<.001	6	view →
BRCA	All	III,IV	+0.751	<.001	6	view →
CHOL	Male	All	+2.276	<.001	5	view →
LUSC	Female	All	+0.682	<.001	4	view →
PRAD	All	All	+0.305	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NCSTN–HNSC

Open the HNSC breakdown →