NCSTN

Across TCGA patient cohorts, NCSTN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCSTN-associated genes across cancer lineages are A-Raf_pS299, MEK1, and mTOR_pS2448. Each is linked with NCSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCSTN-to-partner and partner-to-NCSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NCSTN-low versus NCSTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCSTN→partner) and Y-score (partner→NCSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.122	-3.459	.007	.005	3	2
UCEC	MEK1 →	+0.432	+3.700	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.980	.048	.030	3	2
UCEC	mTOR →	-0.173	-2.087	.005	.005	3	2
UCEC	PCNA →	+0.199	+2.087	.016	.005	3	2
UCEC	STAT3_pY705 →	-0.336	-1.874	<.001	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by NCSTN expression — UCEC

Explore this box plot interactively →