NCSTN

Across TCGA cell cohorts, NCSTN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,015 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCSTN-associated GO terms across cancer lineages are ER-nucleus signaling pathway, Vacuolar transport, and Regulation of ATF6-mediated unfolded protein response. Each is linked with NCSTN in more than 14 cancer types. Because this analysis shows association rather than direction, both NCSTN-to-partner and partner-to-NCSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-nucleus signaling pathway grouped by NCSTN-low versus NCSTN-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCSTN→partner) and Y-score (partner→NCSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ER-nucleus signaling pathway →	+0.140	+1.139	<.001	<.001	3	14
STOMACH	Vacuolar transport →	+0.045	+0.613	.009	.002	2	15
BLOOD_Myeloma	Regulation of ATF6-mediated unfolded protein response →	+0.185	+0.881	.003	.007	2	15
UPPER_AERODIGESTIVE_TRACT	Lysosomal transport →	+0.043	+0.664	.009	.004	3	14
STOMACH	Membrane protein ectodomain proteolysis →	+0.205	+1.226	<.001	<.001	3	13
STOMACH	Retrograde protein transport, ER to cytosol →	+0.139	+0.893	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,015 associations by consensus.

ER-nucleus signaling pathway by NCSTN expression — URINARY_TRACT

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