NCSTN

Across TCGA cell cohorts, NCSTN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCSTN-associated genes across cancer lineages are SSX5, CCDC195, and HPGDS. Each is linked with NCSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCSTN-to-partner and partner-to-NCSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSX5 grouped by NCSTN-low versus NCSTN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCSTN→partner) and Y-score (partner→NCSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SSX5 →	+0.202	+2.968	.004	.008	3	1
BLOOD_Leukemia	CCDC195 →	+1.114	+3.266	<.001	.003	3	1
LARGE_INTESTINE	HPGDS →	+0.028	+3.772	.001	.003	3	1
LARGE_INTESTINE	NUPR2 →	+0.255	+3.688	<.001	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SSX5 by NCSTN expression — BLOOD_Leukemia

Explore this box plot interactively →