NCOR1

Across TCGA patient cohorts, NCOR1 mutation is significantly associated with the RNA expression of many other genes, with 9,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOR1-associated genes across cancer lineages are YTHDF2, NANS, and ECHS1. Each is linked with NCOR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NCOR1-to-partner and partner-to-NCOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YTHDF2 grouped by NCOR1-low versus NCOR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOR1→partner) and Y-score (partner→NCOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YTHDF2 →	+0.298	+1.502	<.001	<.001	3	5
STAD	NANS →	+0.606	+2.355	<.001	<.001	3	5
STAD	ECHS1 →	+0.465	+2.355	<.001	<.001	3	5
STAD	TACC3 →	+0.562	+2.737	.002	.002	3	5
UCEC	PPM1D →	+0.333	+1.457	<.001	<.001	3	5
UCEC	COX10 →	+0.433	+2.029	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,247 associations by consensus.

YTHDF2 by NCOR1 expression — UCEC

Explore this box plot interactively →