NCOA7

Across TCGA pan-cancer cohorts, NCOA7 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated NCOA7 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NCOA7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NCOA7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and KICH are the cancer types where NCOA7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.409	0.814	<.001	44	view →
UCEC	DFS	Median	II,III,IV	1.000	0.424	.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
ESCA	OS	Median	All	0.211	0.700	.020	9	view →
LIHC	DFS	Median	II,III,IV	0.059	0.429	<.001	6	view →
SKCM	DFS	Median	III,IV	0.158	0.653	.022	3	view →
LUSC	DFS	Median	All	0.322	0.711	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

NCOA7–LUAD (OS)

Open the LUAD breakdown →