NCOA7

Across TCGA pan-cancer cohorts, NCOA7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NCOA7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NCOA7 RNA is repressed in tumor relative to normal tissue. In most cancer types NCOA7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where NCOA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCOA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.152	<.001	12	view →
KICH	All	II,III,IV	−1.616	<.001	10	view →
BLCA	All	All	−0.804	.004	10	view →
STAD	All	III,IV	+1.174	<.001	8	view →
LUSC	Male	II,III,IV	−1.738	<.001	7	view →
KIRP	All	All	−1.049	<.001	7	view →
BRCA	All	III,IV	−1.501	<.001	6	view →
COAD	Male	II,III,IV	+0.904	<.001	6	view →
CHOL	Male	All	+2.296	<.001	5	view →
READ	All	All	+1.018	.004	3	view →
ESCA	All	All	+1.671	.003	2	view →
UCEC	All	All	−0.668	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NCOA7–KIRC

Open the KIRC breakdown →