NCOA7

Across TCGA patient cohorts, NCOA7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOA7-associated genes across cancer lineages are PDCD4, EGFR, and eIF4E. Each is linked with NCOA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both NCOA7-to-partner and partner-to-NCOA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NCOA7-low versus NCOA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA7→partner) and Y-score (partner→NCOA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.343	-1.169	.011	.017	3	3
UCEC	EGFR →	-0.142	-1.362	.002	.034	3	2
UCEC	eIF4E →	+0.188	+4.013	.001	<.001	3	2
UCEC	ACC1 →	+0.328	+1.169	.001	.017	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-1.514	.002	.014	3	2
UCEC	p27_pT157 →	-0.057	-1.986	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by NCOA7 expression — UCEC

Explore this box plot interactively →