NCOA7

Across TCGA cell cohorts, NCOA7 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCOA7-associated genes across cancer lineages are SHISA6, IL36B, and CFC1. Each is linked with NCOA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCOA7-to-partner and partner-to-NCOA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHISA6 grouped by NCOA7-low versus NCOA7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA7→partner) and Y-score (partner→NCOA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SHISA6 →	+0.023	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	IL36B →	+0.035	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CFC1 →	+0.879	+4.867	<.001	.009	3	1
CNS	TAS2R60 →	+0.020	+5.357	<.001	.001	3	1
LARGE_INTESTINE	CENPM →	+0.896	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.630	+3.299	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

SHISA6 by NCOA7 expression — BLOOD_Lymphoma

Explore this box plot interactively →