NCOA5

Across TCGA cell cohorts, NCOA5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCOA5-associated genes across cancer lineages are TNP1, KHDC3L, and CHRNA2. Each is linked with NCOA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCOA5-to-partner and partner-to-NCOA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by NCOA5-low versus NCOA5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA5→partner) and Y-score (partner→NCOA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TNP1 →	+0.351	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	KHDC3L →	+0.032	+4.215	<.001	.002	3	1
LARGE_INTESTINE	CHRNA2 →	+0.095	+3.453	<.001	.009	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.256	+3.766	<.001	.004	3	1
STOMACH	KRTAP10-7 →	+0.026	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TNP1 by NCOA5 expression — CNS

Explore this box plot interactively →