NCOA3

Across TCGA pan-cancer cohorts, NCOA3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NCOA3 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NCOA3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NCOA3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where NCOA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.946	0.769	.007	20	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.800	.014	14	view →
UCEC	DFS	Median	II,III,IV	0.539	0.868	.027	8	view →
PDAC	DFS	Tertile	All	0.937	0.695	.007	5	view →
HNSC	DFS	Tertile	III,IV	0.733	0.921	.011	4	view →
LSCC	DFS	Quartile	III,IV	1.000	0.555	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NCOA3–CCRCC (OS)

Open the CCRCC breakdown →