NCOA3

Across TCGA pan-cancer cohorts, NCOA3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NCOA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NCOA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCOA3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where NCOA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCOA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.059	<.001	11	view →
LIHC	All	II,III,IV	+0.885	<.001	8	view →
STAD	All	II,III,IV	+0.848	<.001	7	view →
BLCA	All	All	+0.686	.002	7	view →
LUSC	Male	All	+0.647	<.001	6	view →
BRCA	All	III,IV	+0.542	<.001	6	view →
CHOL	Male	All	+1.866	<.001	5	view →
LUAD	All	All	+0.344	.003	3	view →
THCA	All	All	−0.343	.001	3	view →
KICH	Female	All	−0.519	.026	2	view →
UCEC	All	All	−0.425	.029	2	view →
COAD	Male	All	+0.400	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NCOA3–HNSC

Open the HNSC breakdown →