NCOA3

Across TCGA patient cohorts, NCOA3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCOA3-associated genes across cancer lineages are PDCD4, PKC-b-II_pS660, and ER-alpha. Each is linked with NCOA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NCOA3-to-partner and partner-to-NCOA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NCOA3-low versus NCOA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA3→partner) and Y-score (partner→NCOA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.542	-1.999	<.001	.008	3	4
UCEC	PKC-b-II_pS660 →	-0.181	-1.415	.035	.010	3	3
UCEC	ER-alpha →	-0.555	-1.584	.029	.034	3	2
UCEC	FoxM1 →	+0.180	+1.893	.025	<.001	3	2
UCEC	FOXO3a →	-0.069	-1.410	.029	.022	3	2
UCEC	INPP4B →	-0.235	-2.321	.019	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PDCD4 by NCOA3 expression — UCEC

Explore this box plot interactively →