NCOA3

Across TCGA cell cohorts, NCOA3 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCOA3-associated genes across cancer lineages are LRRC3B, REG1B, and OR4D11. Each is linked with NCOA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCOA3-to-partner and partner-to-NCOA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3B grouped by NCOA3-low versus NCOA3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCOA3→partner) and Y-score (partner→NCOA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRRC3B →	+0.056	+4.054	<.001	.004	3	2
LARGE_INTESTINE	REG1B →	+1.667	+2.933	.003	.003	3	2
SKIN	OR4D11 →	+0.026	+4.437	<.001	.004	3	1
SKIN	MRGPRG →	+0.016	+4.437	<.001	.004	3	1
SKIN	C1QTNF8 →	+0.086	+3.930	<.001	.003	3	1
SKIN	AQP12B →	+0.052	+4.155	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

LRRC3B by NCOA3 expression — SKIN

Explore this box plot interactively →