NCMAP-DT

Across TCGA pan-cancer cohorts, NCMAP-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NCMAP-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NCMAP-DT RNA is repressed in tumor relative to normal tissue. In most cancer types NCMAP-DT is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and THCA are the cancer types where NCMAP-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCMAP-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.149	<.001	11	view →
BRCA	All	III,IV	−0.119	<.001	6	view →
THCA	Male	All	−0.430	<.001	5	view →
KICH	All	All	−0.165	.002	5	view →
KIRP	All	IV	−0.037	<.001	5	view →
LUSC	Female	All	−0.180	<.001	4	view →
CHOL	All	All	−0.372	.008	2	view →
LIHC	Female	All	−0.187	.015	2	view →
LUAD	Female	All	+0.182	.009	2	view →
BLCA	Female	All	+0.127	.046	2	view →
HNSC	All	II,III,IV	−0.072	.036	2	view →
STAD	All	IV	−0.120	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NCMAP-DT–KIRC

Open the KIRC breakdown →