NCLN

Across TCGA patient cohorts, NCLN mutation is significantly associated with the RNA expression of many other genes, with 854 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCLN-associated genes across cancer lineages are KATNBL1P2, RNU6-217P, and LINC00572. Each is linked with NCLN in more than 1 cancer types. Because this analysis shows association rather than direction, both NCLN-to-partner and partner-to-NCLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KATNBL1P2 grouped by NCLN-low versus NCLN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCLN→partner) and Y-score (partner→NCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KATNBL1P2 →	+0.052	+3.766	<.001	.005	3	2
LUAD	RNU6-217P →	+0.284	+7.930	<.001	.008	3	2
BLCA	LINC00572 →	+0.128	+5.588	<.001	.004	3	2
BLCA	SNX18P25 →	+0.056	+5.685	<.001	.003	3	2
STAD	TTTY2B →	+0.009	+4.567	.003	.008	3	2
SKCM	ISCUP1 →	+0.055	+4.469	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 854 associations by consensus.

KATNBL1P2 by NCLN expression — SKCM

Explore this box plot interactively →