NCL

Across TCGA patient cohorts, NCL protein abundance is significantly associated with the protein abundance of many other proteins, with 28,268 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NCL-associated proteins across cancer lineages are MPHOSPH10, MRTO4, and MSH6. Each is linked with NCL in more than 9 cancer types. Because this analysis shows association rather than direction, both NCL-to-partner and partner-to-NCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NCL versus MPHOSPH10 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NCL→partner) and Y-score (partner→NCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MPHOSPH10 →	+0.460	+0.429	<.001	<.001	3	10
GBM	MRTO4 →	+0.481	+0.474	<.001	<.001	3	10
LSCC	MSH6 →	+0.543	+0.403	<.001	<.001	3	10
BRCA	NAT10 →	+0.375	+0.338	<.001	<.001	3	10
GBM	ASH2L →	+0.381	+0.559	<.001	<.001	3	10
GBM	BCLAF1 →	+0.381	+0.472	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,268 associations by consensus.

NCL vs MPHOSPH10 — LSCC

Explore this scatter interactively →