NCL

Across TCGA patient cohorts, NCL mutation is significantly associated with the RNA expression of many other genes, with 2,370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCL-associated genes across cancer lineages are LINC02639, RNU2-23P, and RAB11AP1. Each is linked with NCL in more than 2 cancer types. Because this analysis shows association rather than direction, both NCL-to-partner and partner-to-NCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02639 grouped by NCL-low versus NCL-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCL→partner) and Y-score (partner→NCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LINC02639 →	+0.147	+5.039	<.001	.008	3	3
READ	RNU2-23P →	+0.590	+5.925	<.001	.002	3	2
READ	RAB11AP1 →	+0.354	+5.039	<.001	.008	3	2
READ	LINC01262 →	+0.176	+5.039	<.001	.008	3	2
READ	MTND1P22 →	+0.142	+5.039	<.001	.008	3	2
BRCA	SLC20A1P3 →	+0.021	+4.548	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,370 associations by consensus.

LINC02639 by NCL expression — READ

Explore this box plot interactively →