NCL

Across TCGA patient cohorts, NCL mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCL-associated genes across cancer lineages are PCNA, ASNS, and EGFR_pY1068. Each is linked with NCL in more than 1 cancer types. Because this analysis shows association rather than direction, both NCL-to-partner and partner-to-NCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NCL-low versus NCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCL→partner) and Y-score (partner→NCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.249	+3.169	.005	.018	3	2
UCEC	ASNS →	+0.591	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.225	-1.807	.030	.027	3	1
UCEC	eIF4E →	+0.209	+3.584	.016	.002	3	1
UCEC	eIF4G →	+0.254	+2.999	.047	.035	3	1
UCEC	JNK2 →	+0.251	+1.807	.002	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by NCL expression — UCEC

Explore this box plot interactively →