NCL

Across TCGA cell cohorts, NCL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,851 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NCL-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of SSU-rRNA. Each is linked with NCL in more than 19 cancer types. Because this analysis shows association rather than direction, both NCL-to-partner and partner-to-NCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by NCL-low versus NCL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCL→partner) and Y-score (partner→NCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.173	+0.898	<.001	<.001	3	20
BONE	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.173	+0.960	<.001	<.001	3	20
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.124	+0.908	<.001	<.001	3	19
BONE	Replication fork processing →	+0.109	+0.632	.005	.006	3	19
BONE	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.166	+0.928	<.001	<.001	3	19
LARGE_INTESTINE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.108	+0.738	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,851 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by NCL expression — BONE

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