NCKAP5L

Across TCGA patient cohorts, NCKAP5L mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCKAP5L-associated genes across cancer lineages are Cyclin-B1, RBM15, and 4E-BP1. Each is linked with NCKAP5L in more than 3 cancer types. Because this analysis shows association rather than direction, both NCKAP5L-to-partner and partner-to-NCKAP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NCKAP5L-low versus NCKAP5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP5L→partner) and Y-score (partner→NCKAP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.643	+3.906	<.001	<.001	3	4
UCEC	RBM15 →	+0.212	+1.820	.040	.014	3	3
UCEC	4E-BP1 →	+0.336	+2.000	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.194	+1.857	<.001	.004	3	3
COAD	4E-BP1_pT70 →	+0.160	+2.423	<.001	.001	3	3
STAD	Annexin_VII →	-0.178	-3.000	.036	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Cyclin-B1 by NCKAP5L expression — UCEC

Explore this box plot interactively →