NCKAP5L

Across TCGA pan-cancer cohorts, NCKAP5L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NCKAP5L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NCKAP5L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCKAP5L is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

KIRP, HNSC, and COAD are the cancer types where NCKAP5L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCKAP5L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.024	<.001	11	view →
HNSC	Male	III,IV	+0.875	<.001	11	view →
COAD	Female	II,III,IV	+0.712	<.001	10	view →
KIRC	All	III,IV	+0.435	<.001	9	view →
LIHC	All	II,III,IV	+0.753	<.001	8	view →
BRCA	All	II,III,IV	−0.516	<.001	6	view →
LUAD	Male	All	−0.586	<.001	5	view →
STAD	Male	II,III,IV	+0.851	.010	4	view →
CHOL	All	All	+1.849	<.001	3	view →
BLCA	Female	All	+0.653	.024	3	view →
PRAD	All	All	−0.545	<.001	2	view →
PAAD	Male	All	−0.419	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NCKAP5L–KIRP

Open the KIRP breakdown →