NCKAP5L

Across TCGA cell cohorts, NCKAP5L mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NCKAP5L-associated genes across cancer lineages are MAPK8, CCNC, and RAP1GAP2. Each is linked with NCKAP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both NCKAP5L-to-partner and partner-to-NCKAP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK8 grouped by NCKAP5L-low versus NCKAP5L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCKAP5L→partner) and Y-score (partner→NCKAP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAPK8 →	+0.713	+3.537	.002	.001	3	2
LARGE_INTESTINE	CCNC →	+0.638	+3.364	.001	.002	3	2
LARGE_INTESTINE	RAP1GAP2 →	+0.954	+3.364	.001	.002	3	2
LARGE_INTESTINE	FILIP1L →	-1.061	-3.278	.009	.006	3	2
LARGE_INTESTINE	ZNF57 →	+0.584	+3.064	<.001	.009	3	2
LARGE_INTESTINE	FOXE3 →	+0.116	+2.559	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

MAPK8 by NCKAP5L expression — LARGE_INTESTINE

Explore this box plot interactively →