NCK1

Across TCGA pan-cancer cohorts, NCK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NCK1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NCK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NCK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where NCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.601	0.896	.005	10	view →
GBM	OS	Median	All	0.708	0.907	.003	8	view →
PDAC	OS	Median	IV	0.491	0.836	.024	4	view →
LUAD	OS	Quartile	All	0.853	0.553	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NCK1–CCRCC (DFS)

Open the CCRCC breakdown →