NCK1

Across TCGA patient cohorts, NCK1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCK1-associated genes across cancer lineages are EGFR_pY1068, Gab2, and MAPK_pT202_Y204. Each is linked with NCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCK1-to-partner and partner-to-NCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NCK1-low versus NCK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK1→partner) and Y-score (partner→NCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.307	-3.700	.008	.001	3	1
UCEC	Gab2 →	+0.388	+3.169	.019	.019	3	1
UCEC	MAPK_pT202_Y204 →	-0.545	-3.169	.012	.019	3	1
UCEC	Annexin-1 →	+0.604	+2.189	.013	.034	3	1
UCEC	Tuberin →	+0.360	+2.469	.004	.010	3	1
UCEC	VEGFR2 →	+0.325	+2.598	.019	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by NCK1 expression — UCEC

Explore this box plot interactively →