NCK1

Across TCGA cell cohorts, NCK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,735 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NCK1-associated GO terms across cancer lineages are Regulation of cap-dependent translational initiation, Positive regulation of cap-dependent translational initiation, and Regulation of cap-independent translational initiation. Each is linked with NCK1 in more than 19 cancer types. Because this analysis shows association rather than direction, both NCK1-to-partner and partner-to-NCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cap-dependent translational initiation grouped by NCK1-low versus NCK1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK1→partner) and Y-score (partner→NCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of cap-dependent translational initiation →	+0.263	+1.125	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Positive regulation of cap-dependent translational initiation →	+0.263	+1.125	<.001	<.001	3	20
BREAST	Regulation of cap-independent translational initiation →	+0.186	+1.434	<.001	<.001	3	20
BREAST	Positive regulation of cap-independent translational initiation →	+0.186	+1.434	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of cytoplasmic translational initiation →	+0.216	+0.813	.003	.002	3	14
OESOPHAGUS	Regulation of cytoplasmic translational initiation →	+0.172	+0.636	.006	.008	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,735 associations by consensus.

Regulation of cap-dependent translational initiation by NCK1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →