NCK1

Across TCGA cell cohorts, NCK1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible NCK1-associated genes across cancer lineages are IDI2, OR5AK2, and SMCP. Each is linked with NCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCK1-to-partner and partner-to-NCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by NCK1-low versus NCK1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK1→partner) and Y-score (partner→NCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IDI2 →	+0.033	+5.087	<.001	.004	3	2
BLOOD_Leukemia	OR5AK2 →	+0.066	+5.969	<.001	.001	3	2
BLOOD_Lymphoma	SMCP →	+0.030	+4.867	.001	.009	3	2
BLOOD_Lymphoma	IFNA1 →	+0.154	+4.867	<.001	.009	3	2
URINARY_TRACT	KRTAP2-1 →	+0.133	+5.087	<.001	.004	3	1
URINARY_TRACT	SCT →	+0.153	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

IDI2 by NCK1 expression — URINARY_TRACT

Explore this box plot interactively →