NCK1-DT

Across TCGA pan-cancer cohorts, NCK1-DT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NCK1-DT data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NCK1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NCK1-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

LIHC, SKCM, and COAD are the cancer types where NCK1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.407	0.736	<.001	65	view →
SKCM	OS	Tertile	All	0.453	0.274	<.001	51	view →
COAD	DFS	Median	III,IV	0.380	0.667	<.001	48	view →
KICH	DFS	Quartile	II,III,IV	0.375	1.000	.006	47	view →
UVM	DFS	Tertile	III,IV	0.243	0.856	.004	37	view →
UCS	OS	Median	II,III,IV	0.613	0.224	.003	34	view →
UCEC	DFS	Median	All	0.543	0.745	<.001	34	view →
LUAD	DFS	Quartile	III,IV	0.582	0.258	.010	30	view →
HNSC	DFS	Quartile	IV	0.750	0.524	.001	29	view →
MESO	DFS	Quartile	All	0.209	0.780	.006	15	view →
STAD	DFS	Tertile	All	0.618	0.482	.026	14	view →
PAAD	OS	Median	All	0.525	0.747	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NCK1-DT–LIHC (OS)

Open the LIHC breakdown →